Package: POWSC
Type: Package
Title: Simulation, power evaluation, and sample size recommendation for
        single cell RNA-seq
Version: 1.9.0
Authors@R: c(person("Kenong","Su", email ="kenong.su@emory.edu", role = c("aut","cre")),person("Hao","Wu", email ="hao.wu@emory.edu", role ="aut"))
Description: Determining the sample size for adequate power to detect statistical significance is a crucial step at the design stage for high-throughput experiments.
            Even though a number of methods and tools are available for sample size calculation for microarray and RNA-seq in the context of differential expression (DE),
            this topic in the field of single-cell RNA sequencing is understudied. Moreover, the unique data characteristics present in scRNA-seq such as sparsity and heterogeneity increase the challenge.
            We propose POWSC, a simulation-based method, to provide power evaluation and sample size recommendation for single-cell RNA sequencing DE analysis.
            POWSC consists of a data simulator that creates realistic expression data, and a power assessor that provides a comprehensive evaluation
            and visualization of the power and sample size relationship.
License: GPL-2
Encoding: UTF-8
LazyData: true
biocViews: DifferentialExpression, ImmunoOncology, SingleCell, Software
Depends: R (>= 4.1), Biobase, SingleCellExperiment, MAST
Imports: pheatmap, ggplot2, RColorBrewer, grDevices,
        SummarizedExperiment, limma
Suggests: rmarkdown, knitr, testthat (>= 3.0.0), BiocStyle
VignetteBuilder: knitr
RoxygenNote: 7.1.1
git_url: https://git.bioconductor.org/packages/POWSC
git_branch: devel
git_last_commit: 0061450
git_last_commit_date: 2023-04-25
Date/Publication: 2023-05-04
NeedsCompilation: no
Packaged: 2023-05-05 02:13:23 UTC; biocbuild
Author: Kenong Su [aut, cre],
  Hao Wu [aut]
Maintainer: Kenong Su <kenong.su@emory.edu>
Built: R 4.3.0; ; 2023-05-05 14:10:05 UTC; windows
