<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">
<html xmlns="http://www.w3.org/1999/xhtml" dir="ltr" lang="en-US"
prefix="og: http://ogp.me/ns#">
  <head>
  <meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
  <meta http-equiv="Content-Language" content="en-us" />
  <meta name="robots" content="all" />
  

  <meta property="og:title" content="DNaseR" />
  <meta property="og:type" content="website" />
  <meta property="og:site_name" content="Bioconductor" />
  <meta property="og:description" content="Strand-specific digital genomic footprinting in DNase-seq data. The cumulative Skellam distribution function (package 'skellam') is used to detect significant normalized count differences of opposed sign at each DNA strand. This is done in order to determine the protein-binding footprint flanks. Preprocessing of the mapped reads is recommended before running DNaseR (e.g., quality checking and removal of sequence-specific bias)." />
  <meta property="og:url" content="http://bioconductor.org/packages/DNaseR/" />
  <meta property="og:image" content="http://bioconductor.org/images/logo/jpg/bioconductor_logo_rgb.jpg" />



  
  
  
    <script type="text/javascript" src="//ajax.googleapis.com/ajax/libs/jquery/1.5.1/jquery.min.js"></script>
    <script type="text/javascript">
        if (!window.location.href.match(/bioconductor\.org|\/\/localhost/i)) {
            var mirror = true;
            document.write('<base href="//www.bioconductor.org"/>\n');
        } 
    </script>
  
  
  <script src="/js/jquery.tools.min.js"></script>

  
  
  <title>Bioconductor - DNaseR</title>
  <link rel="stylesheet" type="text/css" href="/style/bioconductor.css" media="screen" />
  <link rel="SHORTCUT ICON" type="image/x-icon" href="/favicon.ico" />
  <link rel="ICON" type="image/x-icon" href="/favicon.ico" />
  <script type="text/javascript" src="/js/bioconductor.js"></script>
 
  <script type="text/javascript" src="/js/jquery.corner.js"></script>
  <script type="text/javascript" src="/js/jquery.timeago.js"></script>
  <script type="text/javascript" src="/js/bioc-style.js"></script>
  <script type="text/javascript" src="/js/versions.js"></script>

  <!-- Google Analytics script -->
  <script type="text/javascript">
    var _gaq = _gaq || [];
    _gaq.push(['_setAccount', 'UA-9338486-1']);
    _gaq.push(['_trackPageview']);

    (function() {
      var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
      ga.src = ('https:' == document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
      var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
    })();
  </script>
</head>

  <body>
    <a name="top"></a>

<!-- a few hooks for screen readers -->
<a href="#site-navigation" title="Jump to site nav"></a>

<a href="#site-map" title="Jump to site map"></a>


    <div id="SiteContainer" class="SiteContainer">
      
      <div id="PageContent" class="PageContent WithRightRail">
      

        
        
          <div id="PageBreadcrumbs" class="PageBreadcrumbs">
  <ul>
    
    
    
      
	  	
        <li><a href="/">Home</a></li>
      
    
    
      
	  	
        <li><a href="/packages/2.14/BiocViews.html">Bioconductor 2.14</a></li>
      
    
    
      
	  	
        <li><a href="/packages/2.14/bioc/">Software Packages</a></li>
      
    
    
      
        <li>DNaseR</li>
      
    
  </ul>
</div>

        

        
        
            <div class="tooltip2" id="tooltip">
    <p>To install this package, start R and enter:</p>
<pre>## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("DNaseR")</pre>
    <p> In most cases, you don't need to download the
    package archive at all.</p>
</div>

        <h1>DNaseR</h1>




<table><tr><td>
<a title="Share on Facebook" href="https://www.facebook.com/sharer/sharer.php?u=https%3A%2F%2Fbioconductor.org%2Fpackages%2F2.14%2Fbioc%2Fhtml%2FDNaseR.html"><img height="16" width="16" src="/images/facebook.png"/></a> &nbsp;
<a title= "Share on Twitter" href="https://twitter.com/intent/tweet?url=https%3A%2F%2Fbioconductor.org%2Fpackages%2F2.14%2Fbioc%2Fhtml%2FDNaseR.html&text=DNaseR:DNase%20I%20footprinting%20analysis%20of%20DNase-seq%20data"><img height="16" width="16" src="/images/twitter.png"/></a> &nbsp;
</td></tr></table>


<div class='do_not_rebase'>


    


    <p>This package is for version 2.14 of Bioconductor;
for the stable, up-to-date release version, see
<a href="/packages/DNaseR/">DNaseR</a>.</p>


    

    <h2>DNase I footprinting analysis of DNase-seq data</h2>

    <p>
        Bioconductor version: 2.14
    </p>

    <p>Strand-specific digital genomic footprinting in DNase-seq data. The cumulative Skellam distribution function (package 'skellam') is used to detect significant normalized count differences of opposed sign at each DNA strand. This is done in order to determine the protein-binding footprint flanks. Preprocessing of the mapped reads is recommended before running DNaseR (e.g., quality checking and removal of sequence-specific bias).</p>

    <p>Author: Pedro Madrigal &#x3c;&#x70;&#x6d;&#x31;&#x32;&#x20;&#x61;&#x74;&#x20;&#x73;&#x61;&#x6e;&#x67;&#x65;&#x72;&#x2e;&#x61;&#x63;&#x2e;&#x75;&#x6b;&#x3e; </p>

    <p>Maintainer: Pedro Madrigal &#x3c;&#x70;&#x6d;&#x31;&#x32;&#x20;&#x61;&#x74;&#x20;&#x73;&#x61;&#x6e;&#x67;&#x65;&#x72;&#x2e;&#x61;&#x63;&#x2e;&#x75;&#x6b;&#x3e; </p>



    <div id="bioc_citation_outer">
    <p>Citation (from within R,
      enter <code>citation("DNaseR")</code>):</p>
      <div id="bioc_citation" class="bioc_citation"></div>
    </div>

    <h3>Installation</h3>

    <p>To install this package, start R and enter:</p>


    <pre>## try http:// if https:// URLs are not supported
source("https://bioconductor.org/biocLite.R")
biocLite("DNaseR")</pre>


    <h3>Documentation</h3>



<p>To view documentation for the version of this package installed
    in your system, start R and enter:
</p>
<pre>browseVignettes("DNaseR")</pre>
    <p>&nbsp;</p>



    <table>
        
        
        
            
                
                
                <tr class="row_odd">
                    <td class="docFixedWidth">
                        
                        <a onClick="javascript: pageTracker._trackPageview('../vignettes/DNaseR/inst/doc/DNaseR.pdf'); " href="../vignettes/DNaseR/inst/doc/DNaseR.pdf">PDF</a>
                        
                    </td>
                    <td class="docFixedWidth">
                        
                        <a onClick="javascript: pageTracker._trackPageview('../vignettes/DNaseR/inst/doc/DNaseR.R'); " href="../vignettes/DNaseR/inst/doc/DNaseR.R">R Script</a>
                        
                    </td>
                    <td>DNaseR Vignette</td>
                </tr>

            
        


            
            <tr class="row_even">
                <td class="docFixedWidth">
                    <a onClick="javascript: pageTracker._trackPageview('../manuals/DNaseR/man/DNaseR.pdf'); " href="../manuals/DNaseR/man/DNaseR.pdf">PDF</a>
                </td>
                <td class="docFixedWidth">&nbsp;</td>
                <td>Reference Manual</td>
                
            </tr>


            


            


            


            
                
                <tr class="row_odd">
                    <td class="docFixedWidth">
                        <a href="../licenses/DNaseR/LICENSE">Text</a>
                    </td>
                    <td class="docFixedWidth">&nbsp;</td>
                    <td>LICENSE</td>
                </tr>
                
            

            




    </table>



    <h3>Details</h3>
    
    <table class="details">
        <tr class="row_odd">
            <td>biocViews</td>
            <td><a href="../../BiocViews.html#___Genetics">Genetics</a>, <a href="../../BiocViews.html#___Software">Software</a>, <a href="../../BiocViews.html#___Transcription">Transcription</a></td>
        </tr>

        <tr class="row_even">
            <td>Version</td>
            <td>1.2.0</td>
        </tr>

        
            <tr id="since" class="row_odd">
                <td>In Bioconductor since</td>
                <td>BioC 2.13 (R-3.0) (2.5 years)</td>
            </tr>
        



        <tr class="row_even">
            <td>License</td>
            <td>GPL-2 + file LICENSE</td>
        </tr>

        <tr class="row_odd">
            <td>Depends</td>
            <td>R (>= 2.10.0), <a href="../../bioc/html/IRanges.html">IRanges</a></td>
        </tr>

        <tr class="row_even">
            <td>Imports</td>
            <td><a href="../../bioc/html/Rsamtools.html">Rsamtools</a>, <a href="../../bioc/html/GenomicRanges.html">GenomicRanges</a></td>
        </tr>

        <tr class="row_odd">
            <td>LinkingTo</td>
            <td></td>
        </tr>

        <tr class="row_even">
            <td>Suggests</td>
            <td><a class="cran_package" href="http://cran.rstudio.com/web/packages/RUnit/index.html">RUnit</a>, <a href="../../bioc/html/BiocGenerics.html">BiocGenerics</a></td>
        </tr>

        <tr class="row_odd">
            <td>SystemRequirements</td>
            <td></td>
        </tr>

        <tr class="row_even">
            <td>Enhances</td>
            <td></td>
        </tr>

        <tr class="row_odd">
            <td>URL</td>
            <td><a href=""></a> </td>
        </tr>

        

        <tr class="row_even">
            <td>Depends On Me</td>
            <td></td>
        </tr>

        <tr class="row_odd">
            <td>Imports Me</td>
            <td></td>
        </tr>

        <tr class="row_even">
            <td>Suggests Me</td>
            <td></td>
        </tr>

        
            <tr class="row_odd">
                <td><a href="http://bioconductor.org/checkResults/2.14/bioc-LATEST/DNaseR/">Build Report</a></td>
                <td>&nbsp;</td>
            </tr>
        


    </table>

    <h3 id="archives">Package Archives</h3>

    <p>Follow <a href="/install/#install-bioconductor-packages">
    Installation</a> instructions to use this
    package in your R session.</p>

    

    <table>
        <tr class="row_odd">
            <td>Package Source</td>
            <td class="rpack"><a onClick="javascript: pageTracker._trackPageview('../src/contrib/DNaseR_1.2.0.tar.gz'); " href="../src/contrib/DNaseR_1.2.0.tar.gz">
                DNaseR_1.2.0.tar.gz</a></td>
            </tr>

            <tr class="row_even">
                <td>Windows Binary</td>
                <td class="rpack">
                    
                    
                    <a onClick="javascript: pageTracker._trackPageview('../bin/windows/contrib/3.1/DNaseR_1.2.0.zip'); " href="../bin/windows/contrib/3.1/DNaseR_1.2.0.zip">
                        DNaseR_1.2.0.zip</a> 
                    
                    </td>
                </tr>


                


                    <tr class="row_odd">
                        <td>Mac OS X 10.6 (Snow Leopard)</td>
                        <td class="rpack"><a onClick="javascript: pageTracker._trackPageview('../bin/macosx/contrib/3.1/DNaseR_1.2.0.tgz'); " href="../bin/macosx/contrib/3.1/DNaseR_1.2.0.tgz">
                            DNaseR_1.2.0.tgz</td>
                    </tr>


                


                    <tr class="row_even">
                        <td>Mac OS X 10.9 (Mavericks)</td>
                        <td class="rpack"><a onClick="javascript: pageTracker._trackPageview('../bin/macosx/mavericks/contrib/3.1/DNaseR_1.2.0.tgz'); " href="../bin/macosx/mavericks/contrib/3.1/DNaseR_1.2.0.tgz">
                            DNaseR_1.2.0.tgz</td>
                    </tr>


                


                
                    <tr class="row_odd">
                        <td id="svn_source">Subversion source</td>
                        <td><a href="https://hedgehog.fhcrc.org/bioconductor/branches/RELEASE_2_14/madman/Rpacks/DNaseR/">(username/password: readonly)</a></td>
                    </tr>
                

                
                    <tr class="row_even">
                        <td id="github_source">Git source</td>
                        <td><a href="https://github.com/Bioconductor-mirror/DNaseR/tree/release-2.14">https://github.com/Bioconductor-mirror/DNaseR/tree/release-2.14</a></td>
                    </tr>
                


                    <tr class="row_odd">
                        <td>Package Short Url</td>
                        <td><a title="Canonical url for use in publications, etc., will always redirect to current release version (or devel if package is not in release yet)." href="/packages/DNaseR/">http://bioconductor.org/packages/DNaseR/</a></td>
                    </tr>


                    <tr class="row_even">
                        <td>Package Downloads Report</td>
                        <td><a href="http://bioconductor.org/packages/stats/bioc/DNaseR/">Download Stats</a></td>
                    </tr>

                </table>




</div>

        
        
        
        

        
        
          </div>
          <div id="RightRail" class="RightRail">
          <a name="section-navigation"></a> <!-- accessibility anchor -->
          
  


  
    <div class="shaded_box">
  <img src="/images/inv.gif" align="right" height="200" width="1" alt=""/>
  <p class="box_header">Documentation <span class="olive">&raquo;</span></p>
  <p><em>Bioconductor</em></p>
  <ul>
    <li>Package <a href="/help/package-vignettes/">vignettes</a> and manuals.
    <li><a href="/help/workflows/">Workflows</a> for learning and use.</li>
    <li><a href="/help/course-materials/">Course and conference</a>
      material.</li>
    <li><a href="https://www.youtube.com/user/bioconductor">Videos</a>.</li>
    <li>Community <a href="/help/community/">resources</a>
      and <a href="https://support.bioconductor.org/t/Tutorials/">tutorials</a>.</li>
  </ul>
  <p><em>R</em> / <a href="http://cran.r-project.org/">CRAN</a> packages and
   <a href="http://www.r-project.org/other-docs.html">documentation</a></p>
</div>

  
    <div class="shaded_box">
  <img src="/images/inv.gif" align="right" height="200" width="1" alt=""/>
  <p class="box_header"><a href="https://support.bioconductor.org/">Support</a>
  <span class="olive">&raquo;</span></p>
  <p>
    Please read the <a href="/help/support/posting-guide/">posting
    guide</a>. Post questions about Bioconductor
    to one of the following locations:</p>
  <ul>
    <li><a href="https://support.bioconductor.org/">Support site</a> -
        for questions about Bioconductor packages</li>
    <li><a href="/help/support/#bioc-devel">Bioc-devel</a> mailing
        list - for package developers</li>
  </ul>
</div>

  


        
      </div>
      <div id="SiteGlobalFooter" class="SiteGlobalFooter">

  <span class="global_footer_logo_bc noprint"><img src="/images/logo_global_footer_bioconductor.gif" height="51" width="154" alt=""/></span>
  <span class="global_footer_logo_fhcrc noprint"><a href="http://www.fredhutch.org"><img src="/images/logo_global_footer_fhcrc.gif" height="51" width="154" alt="Fred Hutchinson Cancer Research Center"/></a></span>

  <div class="attribution_copyright">
    <p>Contact us: <a href="https://support.bioconductor.org/">support.bioconductor.org</a></p>
    <p>Copyright &copy; 2003 - 2016, Bioconductor</p>
  </div>

  <a name="site-map"></a> <!-- accessibility anchor -->
  <ul class="footer_nav_list noprint">
    <li class="footer_nav_list_element footer_nav_list_element_0">
      <b><a href="/index.html">Home</a></b>
    </li>
    <li class="footer_nav_list_element footer_nav_list_element_1">
      <ul>
        <li><b><a href="/install/index.html">Install</a></b></li>
        <li><a href="/install/index.html#install-R">Install R</a></li>
        <li><a href="/install/index.html#find-bioconductor-packages">Find Bioconductor Packages</a></li>
        <li><a href="/install/index.html#install-bioconductor-packages">Install Bioconductor Packages</a></li>
        <li><a href="/install/index.html#update-bioconductor-packages">Update Bioconductor Packages</a></li>
      </ul>
    </li>
    <li class="footer_nav_list_element footer_nav_list_element_2">
      <ul>
        <li><b><a href="/help/index.html">Help</a></b></li>
        <li><a href="/help/workflows/">Workflows</a></li>
        <li><a href="/help/package-vignettes/">Package Vignettes</a></li>
        <li><a href="/help/faq/">FAQ</a></li>
        <li><a href="/help/support/">Support</a></li>
        <li><a href="http://cran.r-project.org/">Using R</a></li>
        <li><a href="/help/course-materials/">Courses</a></li>
        <li><a href="/help/publications/">Publications</a></li>
        <li><a href="/help/bioconductor-cloud-ami/">Cloud AMI</a></li>
        <li><a href="/help/community/">Community Resources</a></li>

      </ul>
    </li>
    <li class="footer_nav_list_element footer_nav_list_element_3">
      <ul>
        <li><b><a href="/developers/index.html">Developers</a></b></li>
		<li><a href="/developers/package-guidelines/">Package Guidelines</a></li>
		<li><a href="/developers/package-submission/">Package Submission</a></li>
		<li><a href="/developers/release-schedule/">Release Schedule</a></li>
		<li><a href="/developers/source-control/">Source Control</a></li>
      </ul>
    </li>
    <li class="footer_nav_list_element footer_nav_list_element_4">
      <ul>
        <li><b><a href="/about/index.html">About</a></b></li>
        <li><a href="/about/advisory-board/">Advisory Board</a></li>
        <li><a href="/about/annual-reports/">Annual Reports</a></li>
        <li><a href="/about/core-team/">Core Team</a></li>
        <li><a href="/about/mirrors/">Mirrors</a></li>
        <li><a href="/about/related-projects/">Related Projects</a></li>
      </ul>
    </li>
  </ul>
  <br style="clear:both"/>
  &nbsp;

</div>


<div id="SiteMasthead" class="SiteMasthead">

  <a name="site-navigation"></a> <!-- accessibility anchor -->

  <span class="logo_vanity_bar noprint"></span>

  <a href="/">
	<img src="/images/logo_bioconductor.gif" border="0" class="masthead_logo" height="78" width="260" alt="Bioconductor - open source software for bioinformatics"/>
  </a>

  <div id="SiteMastheadRight" class="SiteMastheadRight">
    <div id="SiteMastheadRightBackground" class="SiteMastheadRightBackground">

      <a name="site-search"></a> <!-- accessibility anchor -->
      <form class="site_search" id="search_form" method="GET"
            action="/help/search/index.html">
        Search: <input id="q" name="q" />
      </form>

      <ul class="masthead_nav noprint">
        <li class="masthead_nav_element" id="masthead_nav_element_1">
          <a href="/">Home</a>
        </li>
        <li class="masthead_nav_element" id="masthead_nav_element_2">
          <a href="/install/">Install</a>
        </li>
        <li class="masthead_nav_element" id="masthead_nav_element_3">
          <a href="/help/">Help</a>
        </li>
        <li class="masthead_nav_element" id="masthead_nav_element_4">
          <a href="/developers/">Developers</a>
        </li>
        <li class="masthead_nav_element" id="masthead_nav_element_5">
          <a href="/about/">About</a>
        </li>
      </ul>

    </div>
  </div>

</div>

    </div>
  </body>
</html>
